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NRF2 Activation in Trp53;p16-deficient Mice Drives Oral Squamous Cell Carcinoma

Cancer Research Communications
February 2024

Samera HH, Rani SS, Wamsley N, Zolkind P, Schrank TP, Major MB, Weissman BE

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Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

Science Signaling
December 2023

LaPak KM, Saeidi S, Bok I, Wamsley NT, Plutzer IB, Bhatt DP, Luo J, Ashrafi G, and Major MB

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Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia

Redox Biology
November 2023

Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman B, Chembo J, Huang C, Li J, Livingston EW, Frank JE, Chen V, Li Y, Weissman B, Yuan H, Williams KP*, M. Major MB*, and Chen X*

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Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria

Cell Reports
November 2023

Speck SL, Bhatt DP, Zhang Q, Adak S, Yin L, Dong G, Feng C, Zhang W, Major MB, Wei X, and Semenkovich CF

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Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC

Molecular & Cellular Proteomics
September 2023

Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le Q-T, Goldfarb D, and Major MB

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KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle

Journal of Virology
March 2023

Danielle L. ChappellPraneet K. SandhuJason P. WongAadra P. BhattXiaoxi LiuSara J. BuhrlageBrenda R. S. TempleMichael B. Major, and Blossom Damania

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NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells

Cancer Research
March 2023

Li Guan, Dhanya K. Nambiar, Hongbin Cao, Vignesh Viswanathan, Shirley Kwok, Angela B. Hui, Yuan Hou, Rachel Hildebrand, Rie von Eyben, Brittany J. Holmes, Junfei Zhao, Christina S. Kong, Nathan Wamsley, Weiruo Zhang, Michael B. Major, Seung W. Seol, John B. Sunwoo, D. Neil Hayes, Maximilian Diehn, and Quynh-Thu Le
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STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity

Advanced Science
November 2022

Zhichuan ZhuXin ZhouHongwei DuErica W. CloerJiaming ZhangLiu MeiYing WangXianming TanAustin J. HepperlaJeremy M. SimonJeanette Gowen CookMichael B. MajorGianpietro Dotti, and Pengda Liu

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Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

Journal of Biological Chemistry
June 2022

Megan J. Agajanian, Frances M. Potjewyd, Brittany M. Bowman, Smaranda Solomon, Kyle M. LaPak, Dhaval P. Bhatt, Jeffery L. Smith, Dennis Goldfarb, Alison D. Axtman, and Michael B. Major
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TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice

Oncogene
May 2022

Samera H. Hamad, Stephanie A. Montgomery, Jeremy M. Simon, Brittany M. Bowman, Kyle B. Spainhower, Ryan M. Murphy, Erik S. Knudsen, Suzanne E. Fenton, Scott H. Randell, Jeremiah R. Holt, D. Neil Hayes, Agnieszka K. Witkiewicz, Trudy G. Oliver, Michael B. Major, and Bernard E. Weissman