2012
CCDC94 functions in the PRP19 complex to protect cells from radiation-induced apoptosis by inhibiting the transcription of P53
PLoS Genetics
August 2012
Shelly Sorrells, Seth Carbonneau, Erik Harrington, Aye T. Chen, Bridgid Hast, Brett Milash, Ujwal Pyati, Michael B. Major,Yi Zhou, Rodney A. Stewart, Leonard I. Zon, A. Thomas Look, and Cicely Jette
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple negative breast cancer
Cell
April 2012
Duncan JS, Whittle MC, Nakamura K, Abell AN, Midland AA, Zawistowski JS, Johnson NL, Granger DA, Vincent Jordan N, Darr DB, Usary J, Kuan PF, Smalley DM, Major MB, He X, Hoadley K, Zhou B, Sharpless NE, Perou CM, Kim WY, Gomez SH, Chen X, Jin J, Frye SV, Earp HS, Graves LM, and Johnson GL
FAM123A binds microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility
Science Signaling
September 2012
Priscila F. Siesser, Marta Motolese, Matthew P. Walker, Dennis Goldfarb, Kelly Gewain, Feng Yan, Rima M. Kulikaukas, Andy J. Chien, Linda Wordeman, and Michael B. Major
WIKI4, a novel inhibitor of Tankyrase and Wnt/β-catenin signaling
PLoS ONE
December 2012
Richard G. James, Kathryn C. Davidson, Katherine A. Bosch, Travis L. Biechele, Nicholas C. Robin, Russell J. Taylor, Michael B. Major, Nathan D. Camp, Kerry Fowler, Timothy J. Martins, and Randall T. Moon
Wilms tumor gene on the X chromosome (WTX) inhibits the degradation of NRF2 through competitive binding to KEAP1
Journal of Biological Chemistry
January 2012
Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, and Moon RT