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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice

Journal of Biological Chemistry
February 2022

Dhaval P. Bhatt, C. Allie Mills, Kristin A. Anderson, Bárbara J. Henriques, Tânia G. Lucas, Sara Francisco, Juan Liu, Olga R. Ilkayeva, Alexander E. Adams, Shreyas R. Kulkarni, Donald S. Backos, Michael B. Major, Paul A. Grimsrud, Cláudio M. Gomes, Matthew D Hirschey

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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract

Nature Communications
January 2022

Jianan Zhang , Morgan E. Walker, Katherine Z. Sanidad, Hongna Zhang, Yanshan Liang, Ermin Zhao, Katherine Chacon-Vargas, Vladimir Yeliseyev, Julie Parsonnet, Thomas D. Haggerty, Guangqiang Wang, Joshua B. Simpson, Parth B. Jariwala , Violet V Beaty, Jun Yang, Haixia Yang, Anand Panigrahy, Lisa M Minter, Daeyoung Kim, John G Gibbons, LinShu Liu, Zhengze Li, Hang Xia, Valentina Borlandelli, Hermen S. Overkleeft, Erica W CloerMichael B. Major , Dennis Goldfarb, Zongwei Cai, Matthew R. Redinbo, Guodong Zhang

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Visualizing an Allosteric Intermediate Using CuAAC Stabalization of an NMR Mixed Labeled Dimer

ACS Chemical Biology
December 2021

Paul J. Sapienza, Michelle M. Currie, Noah M. Lancaster, Kelin Li, Jeffrey Aubé, Dennis GoldfarbErica W. CloerMichael B. Major, Andrew L. Lee

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Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma

Laryngoscope Investigative Otolaryngology
August 2021

Siddharth Sheth, Douglas R. Farquhar, Travis P. Schrank, Wesley Stepp, Angela Mazul, Michele Hayward, Nicholas Lenze, Paul Little, Heejoon Jo, Michael B. Major, Bhishamjit S. Chera, Jose P. Zevallos, D. Neil Hayes

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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

Cell Reports
July 2021

Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian, Ria Jasuja, Dana Q. Lawson, Keanu Davis, Paul W. Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E. Eschbach, Christian Shema Mugisha, Emily M Cousins, Erica W. Cloer, Hung R. Vuong, Laura A. VanBlargan, Adam L. Bailey, Pavlo Gilchuk, James E. Crowe Jr, Michael S. Diamond, D. Neil Hayes, Sean P.J. Whelan, Amjad Horani, Steven L. Brody, Dennis Goldfarb, Michael B. Major, Sebla B. Kutluay

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Genomic heterogeneity and copy number variant burden are associated with poor recurrence-free survival and 11q loss in human papillomavirus-positive squamous cell carcinoma of the oropharynx

Cancer
April 2021

Travis P. Schrank, Nicholas Lenze, Lee P. Landess, Alan Hoyle, Joel Parker, Asim Lal, Siddharth Sheth, Bhishamjit S. Chera, Samip N. Patel, Trevor G. Hackman, Michael B. Major, Natalia Issaeva, Wendell G. Yarbrough

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Autophagy
February 2021

Many authors including Michael B. Major

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TRIM67 Regulates Exocytic Mode and Neuronal Morphogenesis via SNAP47

Cell Reports
February 2021

Fabio L. Urbina, Shalini Menon, Dennis Goldfarb, Reginald Edwards, Michael B. Major, Patrick Brennwald, and Stephanie L. Gupton

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The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Molecular Biology of the Cell
December 2020

Shalini Menon, Dennis Goldfarb, Tsungyo HO, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, Michael B. Major, and Stephanie L. Gupton

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In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

PLoS Biology
December 2020

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffery S. Damrauer, Feng Yan, Joseph S. Harrison, Michael B. Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, and Michael J. Emanuele